H2N2V1, Main, Exploration, bibRecord, 002162

Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys

Identifieur interne : 002162 ( Main/Exploration ); précédent : 002161; suivant : 002163

Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys

Auteurs : Brian R. Murphy [États-Unis] ; Alicia J. Buckler-White [États-Unis] ; William T. London [États-Unis] ; Mark H. Snyder [États-Unis]

Source :

Vaccine [ 0264-410X ] ; 1989.

RBID : ISTEX:8020350C4CEB03A8714A943F8959DB9D1242CBAC

Descripteurs français

KwdFr :
- ARN viral (analyse), Animaux, Gènes viraux, Nucléoprotéines (génétique), Protéines de la matrice virale (génétique), Protéines de liaison à l'ARN, Protéines du core viral, Protéines virales (génétique), Réplication virale, Saimiri, Séquence d'acides aminés, Séquence nucléotidique, Virus de la grippe A (génétique).
MESH :
- analyse : ARN viral.
- génétique : Nucléoprotéines, Protéines de la matrice virale, Protéines virales, Virus de la grippe A.
- Animaux, Gènes viraux, Protéines de liaison à l'ARN, Protéines du core viral, Réplication virale, Saimiri, Séquence d'acides aminés, Séquence nucléotidique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, Genes, Viral, Influenza A virus (genetics), Nucleoproteins (genetics), RNA, Viral (analysis), RNA-Binding Proteins, Saimiri, Viral Core Proteins, Viral Matrix Proteins (genetics), Viral Proteins (genetics), Virus Replication.
MESH :
- chemical , analysis : RNA, Viral.
- chemical , genetics : Nucleoproteins, Viral Matrix Proteins, Viral Proteins.
- genetics : Influenza A virus.
Teeft :
- Amino, Amino Acid Sequence, Amino acid difference, Amino acid differences, Amino acid sequence, Amino acid sequences, Amino acids, Animals, Attenuation, Attenuation phenotype, Avian, Avian influenza, Avian influenza virus, Avian virus, Base Sequence, Gene, Genes, Viral, Genetic basis, Human influenza, Human influenza strains, Human influenza virus, Human virus, Human virus parent, Influenza, Influenza virus, Internal genes, Matrix protein, National institutes, Nucleoprotein, Nucleoprotein gene characterization, Nucleotide, Nucleotide sequence, Phenotype, Proline, RNA-Binding Proteins, Reassortant, Reassortant influenza, Reassortant virus, Reassortant viruses, Reassortants, Replication, Saimiri, Serine, Squirrel, Squirrel monkeys, Structural basis, Surface antigen genes, Vaccine, Viral Core Proteins, Virus, Virus Replication.

Abstract

Abstract: A reassortant virus possessing RNA segment 7, which codes for the M1 and M2 proteins, of the avian influenza A/Mallard/New York/6750/78 (H2N2) virus and the other seven RNA segments of the human influenza A/Udorn/307/72 (H3N2) virus had been shown previously to be markedly restricted in replication in the respiratory tract of squirrel monkeys. In contrast, a reassortant possessing segment 7 of another avian influenza virus, A/Pintail/Alberta/119/79 (H4N6), and the seven other RNA segments from the A/Udorn/72 virus was not restricted. The nucleotide and deduced amino acid sequence of the RNA segment 7 of each virus was determined to identify the structural basis for the attenuation phenotype specified by RNA segment 7 of the A/Mallard/78 virus. Analysis of the deduced amino acid sequences revealed only two amino acid differences in the M1 protein and one difference in the M2 protein, suggesting that the attenuation phenotype of a reassortant virus possessing segment 7 of the A/Mallard/78 virus may be specified by one to three amino acids. Reassortant viruses possessing RNA segment 6, which codes for the nucleoprotein, of either avian influenza virus and the other seven RNA segments of a human influenza virus were also restricted in replication in squirrel monkeys. A comparison of the deduced amino acid sequences of the two avian nucleopeoteins demonstrated only three amino acid differences indicating that these two avian viruses possess NP genes that are highly related. The high degree of relatedness of both the NP and M proteins of these two avian viruses contrasts with their divergent surface antigens. The structural basis for the attenuation phenotype of the NP gene of the A/Mallard/78 virus is being investigated.

Url:

https://api.istex.fr/ark:/67375/6H6-HTKKZK6Z-V/fulltext.pdf

DOI: 10.1016/0264-410X(89)90283-1

Affiliations:

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<term>Influenza A virus (genetics)</term>
<term>Nucleoproteins (genetics)</term>
<term>RNA, Viral (analysis)</term>
<term>RNA-Binding Proteins</term>
<term>Saimiri</term>
<term>Viral Core Proteins</term>
<term>Viral Matrix Proteins (genetics)</term>
<term>Viral Proteins (genetics)</term>
<term>Virus Replication</term>
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<term>Protéines de la matrice virale (génétique)</term>
<term>Protéines de liaison à l'ARN</term>
<term>Protéines du core viral</term>
<term>Protéines virales (génétique)</term>
<term>Réplication virale</term>
<term>Saimiri</term>
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<term>Viral Proteins</term>
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<term>Amino acid differences</term>
<term>Amino acid sequence</term>
<term>Amino acid sequences</term>
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<term>Attenuation</term>
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<term>Avian influenza</term>
<term>Avian influenza virus</term>
<term>Avian virus</term>
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<term>Genes, Viral</term>
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<term>Nucleoprotein gene characterization</term>
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<term>Nucleotide sequence</term>
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<term>RNA-Binding Proteins</term>
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<term>Reassortant influenza</term>
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<term>Structural basis</term>
<term>Surface antigen genes</term>
<term>Vaccine</term>
<term>Viral Core Proteins</term>
<term>Virus</term>
<term>Virus Replication</term>
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<term>Gènes viraux</term>
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<term>Protéines du core viral</term>
<term>Réplication virale</term>
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<front><div type="abstract" xml:lang="en">Abstract: A reassortant virus possessing RNA segment 7, which codes for the M1 and M2 proteins, of the avian influenza A/Mallard/New York/6750/78 (H2N2) virus and the other seven RNA segments of the human influenza A/Udorn/307/72 (H3N2) virus had been shown previously to be markedly restricted in replication in the respiratory tract of squirrel monkeys. In contrast, a reassortant possessing segment 7 of another avian influenza virus, A/Pintail/Alberta/119/79 (H4N6), and the seven other RNA segments from the A/Udorn/72 virus was not restricted. The nucleotide and deduced amino acid sequence of the RNA segment 7 of each virus was determined to identify the structural basis for the attenuation phenotype specified by RNA segment 7 of the A/Mallard/78 virus. Analysis of the deduced amino acid sequences revealed only two amino acid differences in the M1 protein and one difference in the M2 protein, suggesting that the attenuation phenotype of a reassortant virus possessing segment 7 of the A/Mallard/78 virus may be specified by one to three amino acids. Reassortant viruses possessing RNA segment 6, which codes for the nucleoprotein, of either avian influenza virus and the other seven RNA segments of a human influenza virus were also restricted in replication in squirrel monkeys. A comparison of the deduced amino acid sequences of the two avian nucleopeoteins demonstrated only three amino acid differences indicating that these two avian viruses possess NP genes that are highly related. The high degree of relatedness of both the NP and M proteins of these two avian viruses contrasts with their divergent surface antigens. The structural basis for the attenuation phenotype of the NP gene of the A/Mallard/78 virus is being investigated.</div>
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Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys

Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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